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KMID : 0367419700130110015
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Journal of Korean Pediatric Society
1970 Volume.13 No. 11 p.15 ~ p.19
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Treatment of disbetes insipidus with chlorpropamide
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김기복/Kim, Kibok
정규해/박양현/Chung, Kyu-Hae/Park, Yang Hyun
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Abstract
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In two cases of diabetes insipidus (a five-year-old girl and a eight-year-old boy), oral administration of chlorpropamide in doses of 125^250 mg per day produced marked antidiuresis and concentration of urine. It was noted that the agent was effective also in the vasopressin-insensitive case (8-year-old boy). During the treatment endogenous creatinine clearance and the amount of sodium excreted, as well as osmolar clearance incmasedt while free water clearance decreased. The site of action seems to be the distal portions of nephron, and water permeability of the area is enhanced by chlorpropamide, resembling the action of antidiuretic hormone. But the cellular-mechanism of chlorpropamide action seems to be different from that of vasopressin.
When taken proper care of hypoglycemia, chlorpropamide seems to be a drug of choice, making= the frequent injection of vasopressin unnecessary.
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